Gene Symbol |
ARHGEF3
|
Entrez Gene |
50650
|
Alt Symbol |
GEF3, STA3, XPLN
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
Rho guanine nucleotide exchange factor (GEF) 3
|
Other Description |
59.8 kDA protein|RhoGEF protein|exchange factor found in platelets and leukemic and neuronal tissues, XPLN|rho guanine nucleotide exchange factor 3
|
Swissprots |
Q6NUN3 Q59F00 Q4QQQ0 Q7Z4U2 A8K5U7 Q7Z5T2 Q9H7T4 Q9NR81 Q4QQI5 Q4FZB6
|
Accessions |
EAW65325 EAW65326 Q9NR81 AB209661 BAD92898 AF249744 AAF79954 AF433662 AAP97313 AK024340 BAB14891 AK225688 AK291412 BAF84101 AK293864 BAH11616 AK300045 BAH13198 AK302493 BAH13724 AK308178 AL136832 CAB66766 AM392996 CAL37874 AX775923 CAE11661 BC022249 BC054345 AAH54345 BC068513 AAH68513 BC094748 BC098122 AAH98122 BC098272 AAH98272 BC099715 AAH99715 BC104723 AAI04724 DA401228 DC334437 DC334772 XM_005265186 XP_005265243 XM_005265187 XP_005265244 XM_005265188 XP_005265245 XM_011533764 XP_011532066 XM_011533765 XP_011532067 XM_011533766 XP_011532068 XM_011533767 XP_011532069 NM_001128615 NP_001122087 NM_001128616 NP_001122088 NM_001289698 NP_001276627 NM_019555 NP_062455
|
Function |
Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. {ECO:0000269|PubMed:12221096}.
|
Subcellular Location |
Cytoplasm {ECO:0000250}.
|
Tissue Specificity |
Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney. {ECO:0000269|PubMed:10873612, ECO:0000269|PubMed:12221096}.
|