| Gene Symbol |
PTPRE
|
| Entrez Gene |
5791
|
| Alt Symbol |
HPTPE, PTPE, R-PTP-EPSILON
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase, receptor type, E
|
| Other Description |
protein tyrosine phosphatase, receptor type, epsilon polypeptide|receptor-type tyrosine-protein phosphatase epsilon
|
| Swissprots |
Q13345 Q5VWH3 Q96KQ6 Q5VWH4 P23469
|
| Accessions |
EAW49180 EAW49181 EAW49182 EAW49183 EAW49184 EAW49185 EAW49186 P23469 AA362195 AF406557 AAL01375 AJ315969 CAC86583 AJ430580 CAD23182 AK001335 AK026334 AK056111 AK290414 BAF83103 AK291828 BAF84517 AK299498 BAG61455 AK300613 BAG62307 AL832042 CAH10411 BC031078 BC050062 AAH50062 BC071573 BE246451 BI559814 BI910569 BM970048 BQ006544 BU159075 BU742614 BX648180 D20432 DA470230 DA949010 H17674 JF432831 ADZ16048 U36623 AAC50324 X54134 CAA38069 XM_005252691 XP_005252748 XM_005252692 XP_005252749 XM_011539993 XP_011538295 XM_011539994 XP_011538296 XM_011539995 XP_011538297 XM_011539996 XP_011538298 XM_011539997 XP_011538299 XM_011539998 XP_011538300 XM_011539999 XP_011538301 XM_011540000 XP_011538302 XR_945793 NM_006504 NP_006495 NM_130435 NP_569119
|
| Function |
Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). {ECO:0000250}.
|
| Subcellular Location |
Isoform 3: Cytoplasm.
|
| Tissue Specificity |
Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells). {ECO:0000269|PubMed:8610169}.
|