| Gene Symbol |
cpsf2
|
| Entrez Gene |
394394
|
| Alt Symbol |
cpsf2-A
|
| Species |
Xenopus
|
| Gene Type |
protein-coding
|
| Description |
cleavage and polyadenylation specific factor 2, 100kDa
|
| Other Description |
CPSF 100 kDa subunit|cleavage and polyadenylation specificity factor 100 kDa subunit|cleavage and polyadenylation specificity factor subunit 2
|
| Swissprots |
Q9W799
|
| Accessions |
Q9W799 AF139986 AAD33061 NM_001087654 NP_001081123
|
| Function |
CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. In X.laevis this subunit seems to be predominantly involved in cytoplasmic polyadenylation reaction. May also be involved in the histone 3'-end pre-mRNA processing.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12006661}.
|
| Top Pathways |
mRNA surveillance pathway
|