Gene Symbol | LRRTM2 |
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Entrez Gene | 26045 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | leucine rich repeat transmembrane neuronal 2 |
Other Description | leucine-rich repeat neuronal 2 protein|leucine-rich repeat transmembrane neuronal 2 protein|leucine-rich repeat transmembrane neuronal protein 2 |
Swissprots | Q7L770 A8K4U9 A0AVL3 B7ZLN8 O43300 |
Accessions | EAW62125 O43300 AB007876 BAA24846 AK291064 BAF83753 AK297332 BAH12550 AK309790 AY182026 AAO67547 BC028172 BC126408 AAI26409 BC126410 AAI26411 BC143926 AAI43927 DA400927 HQ258294 ADR83048 XM_011543305 XP_011541607 NM_015564 NP_056379 |
Function | Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized to excitatory synapses. {ECO:0000250}. |
Tissue Specificity | Expressed in neuronal tissues. {ECO:0000269|PubMed:12676565}. |
LRRTM2 CRISPR/Cas9 KO Plasmid (h) - sc-407130 from Santa Cruz Biotechnology
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LRRTM2 HDR Plasmid (h) - sc-407130-HDR from Santa Cruz Biotechnology
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LRRTM2 Double Nickase Plasmid (h) - sc-407130-NIC from Santa Cruz Biotechnology
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LRRTM2 Double Nickase Plasmid (h2) - sc-407130-NIC-2 from Santa Cruz Biotechnology
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LRRTM2 CRISPR Activation Plasmid (h) - sc-407130-ACT from Santa Cruz Biotechnology
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LRRTM2 CRISPR Activation Plasmid (h2) - sc-407130-ACT-2 from Santa Cruz Biotechnology
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LRRTM2 Lentiviral Activation Particles (h) - sc-407130-LAC from Santa Cruz Biotechnology
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LRRTM2 Lentiviral Activation Particles (h2) - sc-407130-LAC-2 from Santa Cruz Biotechnology
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LRRTM2 siRNA (h) - sc-91835 from Santa Cruz Biotechnology
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LRRTM2 shRNA Plasmid (h) - sc-91835-SH from Santa Cruz Biotechnology
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LRRTM2 shRNA (h) Lentiviral Particles - sc-91835-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU011141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12782 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12782 from Sigma-Aldrich
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LRRTM2 siRNA (Human) - CRH8675 from Cohesion Biosciences
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shRNA set against Human LRRTM2 (NM_015564.2) - SHH335087 from Creative biogene
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Human LRRTM2 siRNA - orb269177 from Biorbyt
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LRRTM2 shRNA Plasmid (Human) - CHH8675 from Cohesion Biosciences
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