| Gene Symbol | CLASP1 |
|---|---|
| Entrez Gene | 23332 |
| Alt Symbol | MAST1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytoplasmic linker associated protein 1 |
| Other Description | CLIP-associating protein 1|cytoplasmic linker-associated protein 1|multiple asters 1|multiple asters homolog 1|protein Orbit homolog 1 |
| Swissprots | Q8N5B8 O75118 Q5H9P0 F5GWS0 B7ZLX3 A2RU21 Q9BQT5 Q7Z460 Q2KHQ9 |
| Accessions | AAX88872 EAW95252 EAW95253 EAW95254 EAW95255 Q7Z460 AB014522 BAA31597 AF347693 AAQ15051 AJ288057 CAC35156 AK074338 AK091140 AK123216 AK294922 BAH11926 AK297259 BAH12531 AK297420 BAH12576 AK299331 BAH13003 AK301814 BAH13560 AK302393 BAH13694 AY425956 AAR07949 BC032563 AAH32563 BC112940 AAI12941 BC132723 AAI32724 BC144107 AAI44108 BE328429 BX648523 BX648933 CR749627 CAH18421 CR933722 CAI46251 DQ200867 ABB13627 XM_006712373 XP_006712436 XM_006712374 XP_006712437 XM_006712375 XP_006712438 XM_006712377 XP_006712440 XM_006712381 XP_006712444 XM_006712382 XP_006712445 XM_006712383 XP_006712446 XM_006712385 XP_006712448 XM_011510841 XP_011509143 XM_011510842 XP_011509144 XM_011510843 XP_011509145 XM_011510844 XP_011509146 XM_011510845 XP_011509147 XM_011510846 XP_011509148 XM_011510847 XP_011509149 XM_011510848 XP_011509150 XM_011510849 XP_011509151 XM_011510850 XP_011509152 XM_011510851 XP_011509153 XM_011510852 XP_011509154 XM_011510853 XP_011509155 NM_001142273 NP_001135745 NM_001142274 NP_001135746 NM_001207051 NP_001193980 NM_015282 NP_056097 |
| Function | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Subcellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network {ECO:0000305}. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2. |