| Gene Symbol | Vkorc1 |
|---|---|
| Entrez Gene | 27973 |
| Alt Symbol | D7Wsu86e |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | vitamin K epoxide reductase complex, subunit 1 |
| Other Description | phylloquinone epoxide reductase|vitamin K epoxide reductase complex subunit 1|vitamin K1 2,3-epoxide reductase subunit 1|vitamin K1 epoxide reductase (warfarin-sensitive) |
| Swissprots | Q9CRC0 |
| Accessions | EDL17600 EDL17601 Q9CRC0 AK002742 BAB22320 AK003237 BAB22661 AK008509 BAB25708 AK008578 BAB25757 AK013996 BAB29106 BC031732 AAH31732 CD774913 NM_178600 NP_848715 |
| Function | Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:19492146}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Detected in liver. {ECO:0000269|PubMed:19492146}. |
| Top Pathways | Ubiquinone and other terpenoid-quinone biosynthesis |