| Gene Symbol |
Vkorc1
|
| Entrez Gene |
27973
|
| Alt Symbol |
D7Wsu86e
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
vitamin K epoxide reductase complex, subunit 1
|
| Other Description |
phylloquinone epoxide reductase|vitamin K epoxide reductase complex subunit 1|vitamin K1 2,3-epoxide reductase subunit 1|vitamin K1 epoxide reductase (warfarin-sensitive)
|
| Swissprots |
Q9CRC0
|
| Accessions |
EDL17600 EDL17601 Q9CRC0 AK002742 BAB22320 AK003237 BAB22661 AK008509 BAB25708 AK008578 BAB25757 AK013996 BAB29106 BC031732 AAH31732 CD774913 NM_178600 NP_848715
|
| Function |
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:19492146}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Detected in liver. {ECO:0000269|PubMed:19492146}.
|
| Top Pathways |
Ubiquinone and other terpenoid-quinone biosynthesis
|