| Gene Symbol |
Med1
|
| Entrez Gene |
19014
|
| Alt Symbol |
AI480703, CRSP210, DRIP205, PBP, Pparbp, TRAP220, l11Jus15
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 1
|
| Other Description |
PPAR-binding protein|Ppar binding protein|TR-interacting protein 2|TRIP-2|mediator of RNA polymerase II transcription subunit 1|peroxisome proliferator activated receptor binding protein|peroxisome proliferator-activated receptor-binding protein|thyroid hormone receptor-associated protein complex 220 kDa component|thyroid receptor-interacting protein 2
|
| Swissprots |
Q925J9 Q8BW37 A2A528 A2A526 O88323 Q3UHV0 Q6AXD5 Q8BX19 Q8VDQ7 Q925K0
|
| Accessions |
AAN75014 EDL16118 EDL16119 EDL16120 Q925J9 AF000294 AAC31118 AF332073 AAK56101 AF332074 AAK56102 AK005207 AK049203 BAC33607 AK054437 BAC35779 AK135480 AK147199 BAE27757 AK171506 BB846904 BC021440 AAH21440 BC079636 AAH79636 XM_006532502 XP_006532565 XM_006532503 XP_006532566 XM_006532504 XP_006532567 XM_006532505 XP_006532568 XM_011248799 XP_011247101 XR_388366 NM_001080118 NP_001073587 NM_013634 NP_038662 NM_134027 NP_598788
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Essential for embryogenesis, including development of the central nervous system, heart, liver and placenta and for erythropoiesis. Also required for normal transcriptional control of thyroid-stimulating hormone beta (TSHB) in the pituitary. {ECO:0000269|PubMed:10882104, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:14500757, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15150259, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:16137621, ECO:0000269|Pu
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15150259}. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed in the adult, with high levels of expression in the liver, lung, intestinal mucosa, kidney cortex, thymic cortex, splenic follicle and seminiferous epithelium in testis. Also expressed in the adult heart, brain, spleen and skeletal muscle. {ECO:0000269|PubMed:14500757, ECO:0000269|PubMed:9325263}.
|