Gene Symbol | SPAG16 |
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Entrez Gene | 79582 |
Alt Symbol | PF20, WDR29 |
Species | Human |
Gene Type | protein-coding |
Description | sperm associated antigen 16 |
Other Description | WD repeat domain 29|pf20 protein homolog|sperm-associated WD repeat protein|sperm-associated antigen 16 protein |
Swissprots | Q8N9C7 Q68DB3 Q498B7 Q8N0X2 Q658W1 Q9H601 Q6I9Z6 |
Accessions | AAX93063 AAX93092 AAX93125 AAX93264 AAY14888 AAY24171 AAY24242 ABP99004 EAW70515 Q8N0X2 AF310672 AAM63956 AF426740 AAN63530 AF490390 AAM97147 AK026377 BAB15466 AK095036 BAC04481 AK302351 BAG63677 AK310883 AL832962 CAH56274 AW207406 BC009614 AAH09614 BC025379 AAH25379 BC067756 AAH67756 BC100282 AAI00283 CA313710 CR457359 CAG33640 CR749477 CAH18307 XM_006712746 XP_006712809 XM_011511814 XP_011510116 XM_011511815 XP_011510117 XM_011511816 XP_011510118 XM_011511817 XP_011510119 XM_011511818 XP_011510120 XM_011511819 XP_011510121 XM_011511820 XP_011510122 XM_011511821 XP_011510123 XM_011511822 XP_011510124 XM_011511823 XP_011510125 XM_011511824 XP_011510126 XM_011511825 XP_011510127 XM_011511826 XP_011510128 XM_011511827 XP_011510129 XM_011511828 XP_011510130 XM_011511829 XP_011510131 XM_011511830 XP_011510132 XM_011511831 XP_011510133 XM_011511832 XP_011510134 XM_011511833 XP_011510135 XM_011511834 XP_011510136 XM_011511835 XP_011510137 XM_011511836 XP_011510138 XM_011511837 XP_011510139 NM_001025436 NP_001020607 NM_024532 NP_078808 NR_047659 NR_047660 |
Function | Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Note=Detected on the sperm flagellum axoneme. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules (By similarity). {ECO:0000250}. |
Tissue Specificity | Isoform 1 is detected in testis. Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver. {ECO:0000269|PubMed:11867345, ECO:0000269|PubMed:12391165}. |
SPAG16 CRISPR/Cas9 KO Plasmid (h) - sc-413178 from Santa Cruz Biotechnology
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SPAG16 HDR Plasmid (h) - sc-413178-HDR from Santa Cruz Biotechnology
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SPAG16 Double Nickase Plasmid (h) - sc-413178-NIC from Santa Cruz Biotechnology
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SPAG16 Double Nickase Plasmid (h2) - sc-413178-NIC-2 from Santa Cruz Biotechnology
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SPAG16 CRISPR Activation Plasmid (h) - sc-413178-ACT from Santa Cruz Biotechnology
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SPAG16 CRISPR Activation Plasmid (h2) - sc-413178-ACT-2 from Santa Cruz Biotechnology
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SPAG16 Lentiviral Activation Particles (h) - sc-413178-LAC from Santa Cruz Biotechnology
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SPAG16 Lentiviral Activation Particles (h2) - sc-413178-LAC-2 from Santa Cruz Biotechnology
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SPAG16 siRNA (h) - sc-94730 from Santa Cruz Biotechnology
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SPAG16 shRNA Plasmid (h) - sc-94730-SH from Santa Cruz Biotechnology
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SPAG16 shRNA (h) Lentiviral Particles - sc-94730-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN20385 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20385 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05595 from Sigma-Aldrich
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SPAG16 siRNA (Human) - CRJ2406 from Cohesion Biosciences
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SPAG16 - MBS8214358 from MyBioSource
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shRNA set against Human SPAG16 (NM_024532.4) - SHH415816 from Creative biogene
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SPAG16 shRNA Plasmid (Human) - CHJ2406 from Cohesion Biosciences
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SPAG16 miRNA 3'UTR clone - MiUTR3H-12330 from Creative biogene
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