| Gene Symbol |
CENPO
|
| Entrez Gene |
79172
|
| Alt Symbol |
CENP-O, ICEN-36, MCM21R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centromere protein O
|
| Other Description |
centromeric protein O|interphase centromere complex protein 36
|
| Swissprots |
Q96JV3 B2RDC0 D6W536 Q53T55 Q9BU64
|
| Accessions |
AAX93185 AAY14786 EAX00742 EAX00743 EAX00744 Q9BU64 AK027859 BAB55414 AK315483 BAG37867 AL514456 BC002870 AAH02870 BP366489 BX110829 DA001951 DQ572275 HQ447425 ADQ31911 XM_006712102 XP_006712165 XR_244957 XR_244958 NM_001199803 NP_001186732 NM_024322 NP_077298
|
| Function |
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:16932742, ECO:0000269|PubMed:18007590}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
|