Gene Symbol | L2HGDH |
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Entrez Gene | 79944 |
Alt Symbol | C14orf160, L2HGA |
Species | Human |
Gene Type | protein-coding |
Description | L-2-hydroxyglutarate dehydrogenase |
Other Description | 2-hydroxyglutarate dehydrogenase|L-2-hydroxyglutarate dehydrogenase, mitochondrial|L-alpha-hydroxyglutarate dehydrogenase|alpha-hydroxyglutarate oxidoreductase|alpha-ketoglutarate reductase|duranin |
Swissprots | Q9H9P8 Q9BRR1 |
Accessions | CAE90580 EAW65725 Q9H9P8 AK022680 BAB14174 AK292627 BAF85316 AK309294 AY757363 AAV52330 BC006117 AAH06117 CA424871 JF432174 ADZ15391 XM_005268075 XP_005268132 XM_011537166 XP_011535468 XM_011537167 XP_011535469 XM_011537168 XP_011535470 XM_011537169 XP_011535471 XR_943538 NM_024884 NP_079160 |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:16005139}. |
Tissue Specificity | Widely expressed. Highly expressed in brain, testis and muscle. Expressed to a lower extent in lymphocytes, fibroblasts, keratinocytes, placenta, bladder, small intestine, liver and bone marrow. {ECO:0000269|PubMed:15385440}. |
Top Pathways | Butanoate metabolism |
L2HGDH CRISPR/Cas9 KO Plasmid (h) - sc-413307 from Santa Cruz Biotechnology
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L2HGDH HDR Plasmid (h) - sc-413307-HDR from Santa Cruz Biotechnology
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L2HGDH Double Nickase Plasmid (h) - sc-413307-NIC from Santa Cruz Biotechnology
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L2HGDH Double Nickase Plasmid (h2) - sc-413307-NIC-2 from Santa Cruz Biotechnology
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L2HGDH CRISPR Activation Plasmid (h) - sc-413307-ACT from Santa Cruz Biotechnology
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L2HGDH CRISPR Activation Plasmid (h2) - sc-413307-ACT-2 from Santa Cruz Biotechnology
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L2HGDH Lentiviral Activation Particles (h) - sc-413307-LAC from Santa Cruz Biotechnology
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L2HGDH Lentiviral Activation Particles (h2) - sc-413307-LAC-2 from Santa Cruz Biotechnology
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L2HGDH siRNA (h) - sc-92295 from Santa Cruz Biotechnology
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L2HGDH shRNA Plasmid (h) - sc-92295-SH from Santa Cruz Biotechnology
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L2HGDH shRNA (h) Lentiviral Particles - sc-92295-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU077601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11512 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11512 from Sigma-Aldrich
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L2HGDH siRNA (Human) - CRJ2682 from Cohesion Biosciences
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shRNA set against Human L2HGDH (NM_024884.2) - SHH328015 from Creative biogene
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Human L2HGDH siRNA - orb273183 from Biorbyt
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L2HGDH shRNA Plasmid (Human) - CHJ2682 from Cohesion Biosciences
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L2HGDH miRNA 3'UTR clone - MiUTR1H-05546 from Creative biogene
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