NHLRC1

Gene Symbol	NHLRC1
Entrez Gene	378884
Alt Symbol	EPM2A, EPM2B, MALIN, bA204B7.2
Species	Human
Gene Type	protein-coding
Description	NHL repeat containing E3 ubiquitin protein ligase 1
Other Description	E3 ubiquitin-protein ligase NHLRC1|NHL repeat containing 1|NHL repeat-containing protein 1
Swissprots	Q3SYB1 Q6IMH1 Q5VUK7 Q6VVB1
Accessions	EAW55392 Q6VVB1 AY324850 AAQ19671 BC103888 AAI03889 BC103889 AAI03890 BC103890 AAI03891 BK001510 DAA01954 NM_198586 NP_940988
Function	E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. {ECO:0000269|PubMed:15930137, ECO:0000269|PubMed:17908927, ECO:0000269|PubMed:18070875, ECO:0000269|PubMed:19036738, ECO:0000269|PubMed:21505799, ECO:0000269|PubMed:23624058}.
Subcellular Location	Endoplasmic reticulum. Nucleus. Note=Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus.
Tissue Specificity	Expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:12958597}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NHLRC1 protein fragment - ab166392 from Abcam Category Protein Source Wheat germ Species Human

NHLRC1 peptide (385-395) - ab45674 from Abcam Category Peptide Species Human

EPM2A / Laforin Antibody Blocking Peptide - LS-E3365 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPM2A / Laforin Antibody Blocking Peptide - LS-E31329 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

EPM2A / Laforin Antibody Blocking Peptide - LS-E23113 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPM2A / Laforin Antibody Blocking Peptide - LS-E23114 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPM2A / Laforin Antibody Blocking Peptide - LS-E26732 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NHLRC1 Protein - H00378884-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Laforin/EPM2A Protein - H00007957-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Laforin/EPM2A Protein - H00007957-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Laforin/EPM2A Peptide - P0430 from Novus Biologicals Category Peptide Species Human

NHLRC1-Antibody-Center-Blocking-peptide - BP13383c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Goat anti EPM2A antibody Immunizing peptide - orb55061 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

NHLRC1 - H00378884-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NHLRC1 - H00378884-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NHLRC1 fusion protein - Ag15940 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NHLRC1 fusion protein - Ag17248 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human NHLRC1, GST-tagged - NHLRC1-1291H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase NHLRC1(NHLRC1) - CSB-YP740936HU CSB-EP740936HU CSB-BP740936HU CSB-MP740936HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EPM2A Peptide, Human - M34GP05001H from Creative Peptides Category Peptide Source Synthetic. Species Human

NHLRC1 Peptide, Human - M34GP10368H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase NHLRC1 (NHLRC1), Recombinant Protein - MBS1344713 from MyBioSource Category Protein Prices $1,165.00, $1,165.00, $1,395.00, $1,395.00, $1,870.00, $1,870.00, $2,330.00, $2,330.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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