| Gene Symbol |
USP34
|
| Entrez Gene |
9736
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 34
|
| Other Description |
deubiquitinating enzyme 34|ubiquitin carboxyl-terminal hydrolase 34|ubiquitin specific protease 34|ubiquitin thioesterase 34|ubiquitin thiolesterase 34|ubiquitin-specific-processing protease 34
|
| Swissprots |
O60316 B3KWU9 Q9UGA1 Q8N3T9 Q6P6C9 Q3B777 O94834 Q7L8P6 Q8TBW2 Q70CQ2 A8MWD0
|
| Accessions |
EAW99998 Q70CQ2 AB011142 BAA25496 AB018272 BAA34449 AJ586138 CAE51938 AK001193 AK022637 AK023171 AK023845 AK024341 AK124932 AK125898 BAG54261 AK126741 AL050092 CAB43264 AL050376 AL831918 CAD38579 AW293998 BC022783 AAH22783 BC062325 AAH62325 BC107761 AAI07762 BC141839 BX473680 NM_014709 NP_055524
|
| Function |
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}.
|
| Tissue Specificity |
Expressed in brain at low level. {ECO:0000269|PubMed:14715245}.
|