| Gene Symbol |
Wrn
|
| Entrez Gene |
22427
|
| Alt Symbol |
AI846146
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
Werner syndrome homolog (human)
|
| Other Description |
Werner syndrome ATP-dependent helicase homolog|exonuclease WRN
|
| Swissprots |
O09050 Q9Z241 O09053 Q9JKD4 Q9Z242 Q80YP9
|
| Accessions |
AAC72359 EDL35409 O09053 AF091215 AAC78077 AF241636 AAF64490 AK052466 BAC35005 AK143778 AK153824 AK158180 BAE34397 AK161483 AK162801 AK165679 BAE38334 AK171490 BAE42489 BC050921 AAH50921 BC060700 AAH60700 D86526 BAA20269 D86527 BAA20270 U97045 AAB87366 XM_006509091 XP_006509154 XM_006509093 XP_006509156 NM_001122822 NP_001116294 NM_011721 NP_035851
|
| Function |
Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9618508}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation- induced WRN relocation. {ECO:0000250}.
|
| Tissue Specificity |
Expressed ubiquitously in most organs at a low level, highly expressed in testis, ovary and spleen. {ECO:0000269|PubMed:10757812, ECO:0000269|PubMed:9143515}.
|
