| Gene Symbol |
Vps26a
|
| Entrez Gene |
30930
|
| Alt Symbol |
AA407240, HB58, Vps26
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
vacuolar protein sorting 26 homolog A (yeast)
|
| Other Description |
H beta 58|h<beta>58 protein|mVPS26|vacuolar protein sorting-associated protein 26A|vacuole protein sorting 26|vesicle protein sorting 26A
|
| Swissprots |
Q3UD54 Q3THM5 P40336 Q8C1E9 Q3TW99 Q3TGY3
|
| Accessions |
EDL32094 EDL32095 EDL32096 EDL32097 EDL32098 P40336 AK028096 BAC25745 AK086851 AK147989 BAE28271 AK149859 AK150244 BAE29408 AK151360 BAE30335 AK152424 AK159783 BAE35367 AK165853 BAE38415 AK167592 BAE39650 AK168213 BAE40171 AK168537 BAE40415 AK178781 AK190246 AK191033 AK193691 AK195000 AK199658 AK209699 AK216993 BB857335 BC007148 AAH07148 BC058236 AAH58236 CO801094 S41204 AAB22718 XM_006513734 XP_006513797 NM_001113355 NP_001106826 NM_133672 NP_598433
|
| Function |
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC complex seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (By similarity). Required for retrograde transport of lysosomal enzyme r
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15078902}. Endosome membrane {ECO:0000269|PubMed:15078902}; Peripheral membrane protein {ECO:0000269|PubMed:15078902}. Early endosome {ECO:0000269|PubMed:18088321, ECO:0000269|PubMed:21920005}. Note=Predominantly found in early not late endosomes. {ECO:0000269|PubMed:21920005}.
|