| Gene Symbol |
GSTZ1
|
| Entrez Gene |
2954
|
| Alt Symbol |
GSTZ1-1, MAAI, MAI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutathione S-transferase zeta 1
|
| Other Description |
S-(hydroxyalkyl)glutathione lyase|glutathione S-alkyltransferase|glutathione S-aralkyltransferase|glutathione S-aryltransferase|glutathione transferase zeta 1|maleylacetoacetate isomerase|maleylacetone isomerase
|
| Swissprots |
O75430 O43708 Q6IB17 O15308 B2RCK3 A8MWD7 A6NED0 Q9BV63 A6NNB8 Q7Z610
|
| Accessions |
AAC33591 AAD43007 AAF62559 AAP69526 EAW81278 EAW81279 EAW81280 EAW81281 O43708 AB209360 BAD92597 AJ001838 CAA05045 AK094344 AK309054 AK315154 BAG37600 AK315609 BAG37978 BC001453 AAH01453 BC052245 BE958109 BG330365 BG772450 BI559916 BI829992 CR456987 CAG33268 HQ448717 ADQ33195 U86529 AAB96392 XM_005267559 XP_005267616 XM_011536670 XP_011534972 XM_011536671 XP_011534973 NM_001513 NP_001504 NM_145870 NP_665877 NM_145871 NP_665878
|
| Function |
Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. {ECO:0000269|PubMed:10739172}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Mostly expressed in liver followed by kidney, skeletal muscle and brain. Also expressed in melanocytes, synovium, placenta, breast and fetal liver and heart.
|
| Top Pathways |
Tyrosine metabolism
|
