| Gene Symbol |
ADAP2
|
| Entrez Gene |
55803
|
| Alt Symbol |
CENTA2, HSA272195, cent-b
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ArfGAP with dual PH domains 2
|
| Other Description |
arf-GAP with dual PH domain-containing protein 2|centaurin beta|centaurin, alpha 2|centaurin-alpha 2 protein|centaurin-alpha-2|cnt-a2
|
| Swissprots |
Q9NPF8 Q8N4Q6 Q96SD5
|
| Accessions |
EAW80287 EAW80288 EAW80289 Q9NPF8 AJ238994 CAB88383 AJ242782 CAC40651 AJ272195 CAB77266 AK074196 AK074204 AK222526 BAD96246 BC033758 AAH33758 DQ288859 ABB90599 HQ447868 ADQ32352 XM_005258008 XP_005258065 XM_005258011 XP_005258068 XM_006721973 XP_006722036 XM_011524993 XP_011523295 XM_011524994 XP_011523296 NM_018404 NP_060874
|
| Function |
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. {ECO:0000269|PubMed:14690521, ECO:0000305}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:14690521}. Cell membrane {ECO:0000269|PubMed:14690521}. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus.
|
| Tissue Specificity |
Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes. Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow. {ECO:0000269|PubMed:14690521}.
|
