| Gene Symbol |
IGF2BP1
|
| Entrez Gene |
10642
|
| Alt Symbol |
CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1
|
| Species |
Human
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| Gene Type |
protein-coding
|
| Description |
insulin-like growth factor 2 mRNA binding protein 1
|
| Other Description |
IGF-II mRNA-binding protein 1|IGF2 mRNA-binding protein 1|VICKZ family member 1|ZBP-1|coding region determinant-binding protein|insulin-like growth factor 2 mRNA-binding protein 1|zipcode-binding protein 1
|
| Swissprots |
C9JT33 Q9NZI8
|
| Accessions |
EAW94693 EAW94694 EAW94695 EAW94696 Q9NZI8 AF117106 AAD09826 AF198254 AAF37203 AK022617 AK022784 AK074915 BAG52029 AK095573 AK313229 BAG36040 BC152770 AAI52771 BC156957 AAI56958 BP238821 DA758608 DQ227344 ABB46294 XM_005256955 XP_005257012 XM_011524201 XP_011522503 NM_001160423 NP_001153895 NM_006546 NP_006537
|
| Function |
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being transl
|
| Subcellular Location |
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell projection, growth cone. Cell projection, filopodium {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription (By similarity). In the cytoplasm, localizes in cytoplasmic mRNP granules. Colocalizes with microtubules in growth cone filopodia and along neurites in neuronal cells (By similarity). Cytoplasmic colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript. In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited (By similarity). In hippocampal neurons, predominantly located within dendrites, particularly at dendritic branching points in young cells, compared to axo
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| Tissue Specificity |
Mainly expressed in the embryo, including in fetal liver, fetal lung, fetal kidney, fetal thymus (at protein level). Also expressed follicles of ovary, as well as in gonocytes of testis, spermatogonia, semen, oocytes and placenta (at protein level). Expressed in various cancers, including testis and lung cancers (at protein level), as well as kidney, prostate and trachea cancers. {ECO:0000269|PubMed:12921532, ECO:0000269|PubMed:16049158, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:9891060}.
|
| Top Pathways |
MicroRNAs in cancer
|