| Gene Symbol |
EHF
|
| Entrez Gene |
26298
|
| Alt Symbol |
ESE3, ESE3B, ESEJ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ets homologous factor
|
| Other Description |
ESE3 transcription factor|ETS domain-containing transcription factor|ETS homologous factor|epithelium-specific Ets transcription factor 3|hEHF
|
| Swissprots |
Q9UKF9 Q9H509 E9PSB2 Q9Y5V5 D3DR08 Q9NZC4 D3DR10 Q9Y5V4
|
| Accessions |
CAC12700 CAC12701 EAW68162 EAW68163 EAW68164 EAW68165 EAW68166 Q9NZC4 AF124438 AAD30990 AF124439 AAD30991 AF170583 AAF06998 AF203977 AAG35644 AF212848 AAF61670 AK025244 AK309318 AK310867 AL703839 AY882601 AAW80658 BC038995 AAH38995 BF754249 BM821693 BM834021 BM975808 BX486553 CB240726 CD722227 DA460976 DB214606 EU446870 ABZ92399 XM_005252857 XP_005252914 XM_005252860 XP_005252917 XM_005252861 XP_005252918 XM_005252862 XP_005252919 XM_011519983 XP_011518285 XM_011519984 XP_011518286 XM_011519985 XP_011518287 NM_001206615 NP_001193544 NM_001206616 NP_001193545 NM_012153 NP_036285
|
| Function |
Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen- activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. {ECO:0000269|PubMed:10527851, ECO:0000269|PubMed:10644770, ECO:0000269|PubMed:11259407, ECO:0000269|PubMed:12444029, ECO:0000269|PubMed:17027647}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00237, ECO:0000269|PubMed:11259407, ECO:0000269|PubMed:12444029}.
|
| Tissue Specificity |
Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, prostate, and lung. Weakly expressed in kidney and colon. Not detected in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, testis, ovary, small intestine or peripheral blood leukocytes. {ECO:0000269|PubMed:10527851, ECO:0000269|PubMed:10644770, ECO:0000269|PubMed:11259407, ECO:0000269|PubMed:12444029}.
|