MICALL2
| Gene Symbol | MICALL2 |
|---|---|
| Entrez Gene | 79778 |
| Alt Symbol | JRAB, MICAL-L2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | MICAL-like 2 |
| Other Description | MICAL-like protein 2|junctional Rab13-binding protein|molecule interacting with CasL-like 2 |
| Swissprots | Q8TEQ4 Q7Z655 Q9H5F9 Q7RTP4 D3YTD2 Q8IY33 |
| Accessions | EAW87200 EAW87201 Q8IY33 AK027124 BAB15667 AK074068 BAB84894 AK091986 AK093249 AK123990 AK126808 BAC86702 AK127339 AL833704 CAD98087 AY358755 AAQ89115 BC037988 AAH37988 BC039886 BK000467 DAA01346 DA945802 EU832111 ACE87461 EU832205 ACE86775 XM_011515520 XP_011513822 XM_011515521 XP_011513823 XM_011515522 XP_011513824 XM_011515523 XP_011513825 XM_011515524 XP_011513826 XR_926947 NM_024723 NM_182924 NP_891554 |
| Function | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Recycling endosome {ECO:0000250}. Cell projection {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. |
JRAB CRISPR/Cas9 KO Plasmid (h) - sc-410130 from Santa Cruz Biotechnology
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JRAB HDR Plasmid (h) - sc-410130-HDR from Santa Cruz Biotechnology
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JRAB Double Nickase Plasmid (h) - sc-410130-NIC from Santa Cruz Biotechnology
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JRAB Double Nickase Plasmid (h2) - sc-410130-NIC-2 from Santa Cruz Biotechnology
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JRAB CRISPR Activation Plasmid (h) - sc-410130-ACT from Santa Cruz Biotechnology
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JRAB CRISPR Activation Plasmid (h2) - sc-410130-ACT-2 from Santa Cruz Biotechnology
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JRAB Lentiviral Activation Particles (h) - sc-410130-LAC from Santa Cruz Biotechnology
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JRAB Lentiviral Activation Particles (h2) - sc-410130-LAC-2 from Santa Cruz Biotechnology
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JRAB siRNA (h) - sc-89784 from Santa Cruz Biotechnology
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JRAB shRNA Plasmid (h) - sc-89784-SH from Santa Cruz Biotechnology
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JRAB shRNA (h) Lentiviral Particles - sc-89784-V from Santa Cruz Biotechnology
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MICALL2 RNAi - H00079778-R01 from Novus Biologicals
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MICALL2 RNAi - H00079778-R02 from Novus Biologicals
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MISSION® esiRNA - EHU096971 from Sigma-Aldrich
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MISSION® esiRNA - EHU097641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13321 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01214 from Sigma-Aldrich
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MICALL2 siRNA (Human) - CRJ2556 from Cohesion Biosciences
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shRNA set against Human MICALL2 (NM_182924.3) - SHH341883 from Creative biogene
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MICALL2 shRNA Plasmid (Human) - CHJ2556 from Cohesion Biosciences
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MICALL2 miRNA 3'UTR clone - MiUTR3H-15497 from Creative biogene
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