| Gene Symbol |
Stat3
|
| Entrez Gene |
20848
|
| Alt Symbol |
1110034C02Rik, AW109958, Aprf
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
signal transducer and activator of transcription 3
|
| Other Description |
acute phase response factor|acute-phase response factor
|
| Swissprots |
B7ZC17 A2A5D1 P42227
|
| Accessions |
AAK17195 AAL59017 EDL01234 P42227 AK004083 AK079406 AK145486 BAE26464 AK153005 BAE31645 AK153170 AK153472 BAE32023 AK161906 AK184281 AK192932 AK192951 AK193746 AK197148 AY299489 AAQ75418 AY299490 AAQ75419 BC003806 AAH03806 BC019168 AAH19168 BC037688 AAH37688 BY301717 L29278 AAA37254 U06922 AAA19452 U08378 AAA56668 U30709 AAC52612 XM_011248846 XP_011247148 NM_011486 NP_035616 NM_213659 NP_998824 NM_213660 NP_998825
|
| Function |
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G. {ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23401489}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 (By similarity). Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. {ECO:0000250}.
|
| Tissue Specificity |
STAT3A is seen in the liver, spleen, and kidney. STAT3B is also detected in the liver, although in a much less abundant manner. Expressed in the lung and an increase in expression levels seen during methicillin-resistant S.aureus infection. {ECO:0000269|PubMed:23401489}.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells, Inflammatory bowel disease (IBD), Proteoglycans in cancer, Viral carcinogenesis, MicroRNAs in cancer
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