Gene Symbol | Cyp51 |
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Entrez Gene | 13121 |
Alt Symbol | AI426508, CYPLI, Cyp51a1, Ldm, P450-14DM, P450LI |
Species | Mouse |
Gene Type | protein-coding |
Description | cytochrome P450, family 51 |
Other Description | cytochrome P450 51A1|cytochrome P450, 51|cytochrome P450-14DM|cytochrome P45014DM|cytochrome P450LI|lanosterol 14-alpha demethylase|lanosterol 14-alpha-demethylase|sterol 14-alpha demethylase |
Swissprots | Q8BSQ7 Q9JIY3 Q8K0C4 Q9JIP8 |
Accessions | AAF74562 EDL14627 Q8K0C4 AF166266 AAF73986 AK002827 BAB22388 AK028355 BAC25900 AK028815 BAC26134 AK031059 BAC27231 AK050781 AK075764 AK076983 BAC36548 AK179972 AK193495 AK202785 AK207015 AK208162 AK210661 AK217526 BC031813 AAH31813 CB524876 NM_020010 NP_064394 |
Function | Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}. Microsome membrane {ECO:0000305}. |
Top Pathways | Steroid biosynthesis |
CYP51A1 CRISPR/Cas9 KO Plasmid (m) - sc-419931 from Santa Cruz Biotechnology
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CYP51A1 HDR Plasmid (m) - sc-419931-HDR from Santa Cruz Biotechnology
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CYP51A1 Double Nickase Plasmid (m) - sc-419931-NIC from Santa Cruz Biotechnology
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CYP51A1 Double Nickase Plasmid (m2) - sc-419931-NIC-2 from Santa Cruz Biotechnology
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CYP51A1 CRISPR Activation Plasmid (m) - sc-419931-ACT from Santa Cruz Biotechnology
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CYP51A1 CRISPR Activation Plasmid (m2) - sc-419931-ACT-2 from Santa Cruz Biotechnology
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CYP51A1 Lentiviral Activation Particles (m) - sc-419931-LAC from Santa Cruz Biotechnology
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CYP51A1 Lentiviral Activation Particles (m2) - sc-419931-LAC-2 from Santa Cruz Biotechnology
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CYP51A1 siRNA (m) - sc-142739 from Santa Cruz Biotechnology
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CYP51A1 shRNA Plasmid (m) - sc-142739-SH from Santa Cruz Biotechnology
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CYP51A1 shRNA (m) Lentiviral Particles - sc-142739-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU070591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN29582 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29582 from Sigma-Aldrich
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CYP51A1 siRNA (Mouse) - CRM0958 from Cohesion Biosciences
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CYP51A1 - MBS8229842 from MyBioSource
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shRNA set against Mouse Cyp51 (NM_020010.2) - SHH273773 from Creative biogene
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shRNA set against Mouse Cyp51(NM_020010.2) - SHG217945 from Creative biogene
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Mouse CYP51A1 siRNA - orb280434 from Biorbyt
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CYP51A1 shRNA Plasmid (Mouse) - CHM0958 from Cohesion Biosciences
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CYP51 miRNA 3'UTR clone - MiUTR1M-03559 from Creative biogene
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