Gene Symbol | Anpep |
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Entrez Gene | 16790 |
Alt Symbol | AP-M, AP-N, Apn, Cd13, P150 |
Species | Mouse |
Gene Type | protein-coding |
Description | alanyl (membrane) aminopeptidase |
Other Description | alanyl aminopeptidase|aminopeptidase M|aminopeptidase N|aminopeptidase N/CD13|membrane protein p161|microsomal aminopeptidase |
Swissprots | Q91YH8 Q99K63 P97449 |
Accessions | EDL07044 P97449 AI848985 AK143746 BAE25523 AK171427 BAE42445 BC005431 AAH05431 BC017011 AAH17011 BC040792 AAH40792 U77083 AAB19065 XM_006540678 XP_006540741 NM_008486 NP_032512 |
Function | Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May have a role in angiogenesis (By similarity). Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells. {ECO:0000250, ECO:0000269|PubMed:8103749}. |
Subcellular Location | Membrane; Single-pass type II membrane protein. |
Tissue Specificity | Highly expressed in intestinal tract and kidney, present in liver, lymph node, spleen, and brain. Found as well in monocytes, macrophages, dendritic cells, veiled cells and B-cells but not on T-cells and thymocytes. {ECO:0000269|PubMed:8805662}. |
Top Pathways | Hematopoietic cell lineage, Glutathione metabolism, Renin-angiotensin system |
CD13 (M-17) - sc-6996 from Santa Cruz Biotechnology
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Anti-CD13 antibody [R3-63] - ab33489 from Abcam
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Anti-CD13 antibody [R3-63] (Biotin) - ab33480 from Abcam
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Anti-CD13 antibody [R3-63] (FITC) - ab33486 from Abcam
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Anti-CD13 antibody [R3-63] (Phycoerythrin) - ab33490 from Abcam
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Aminopeptidase N/CD13 Antibody [Unconjugated] - AF2335 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) - NB100-64843 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (R3-63) - NBP2-23492 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody [Biotin] - BAF2335 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [Allophycocyanin] - NB100-64843APC from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [PerCP] - NB100-64843PCP from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [Alexa Fluor (R) 700] - NB100-64843AF700 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [Alexa Fluor (R) 647] - NB100-64843AF647 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [Alexa Fluor (R) 488] - NB100-64843AF488 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [Alexa Fluor (R) 405] - NB100-64843AF405 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [DyLight 488] - NB100-64843G from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [DyLight 755] - NB100-64843IR from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [DyLight 350] - NB100-64843UV from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [DyLight 405] - NB100-64843V from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [PE] - NB100-64843PE from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [7C] - NB100-64843V2 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [DyLight 405LS] - NB100-64843V3 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (ER-BMDM1) [DyLight 680] - NB100-64843FR from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (R3-63) [PE] - NB100-63402 from Novus Biologicals
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Aminopeptidase N/CD13 Antibody (R3-63) [FITC] - NB100-63401 from Novus Biologicals
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