| Gene Symbol |
THRAP3
|
| Entrez Gene |
9967
|
| Alt Symbol |
TRAP150
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thyroid hormone receptor associated protein 3
|
| Other Description |
thyroid hormone receptor-associated protein 3|thyroid hormone receptor-associated protein complex 150 kDa component|thyroid hormone receptor-associated protein, 150 kDa subunit
|
| Swissprots |
Q5VTK6 D3DPS5 Q9Y2W1
|
| Accessions |
CAR81494 CAS91510 EAX07379 EAX07380 Q9Y2W1 AF117756 AAD22034 AI754117 AK025408 AK025735 BC002501 AAH02501 BC010997 AAH10997 BC019076 AAH19076 BC037554 AAH37554 BC054046 AAH54046 BC065519 AAH65519 BC112330 AAI12331 BC112350 AAI12351 BG572651 EU446755 ABZ92284 XM_005271371 XP_005271428 XR_246308 NM_005119 NP_005110
|
| Function |
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Media
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:23525231}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10198638}.
|