| Gene Symbol | TXNRD2 |
|---|---|
| Entrez Gene | 10587 |
| Alt Symbol | SELZ, TR, TR-BETA, TR3, TRXR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | thioredoxin reductase 2 |
| Other Description | selenoprotein Z|thioredoxin reductase 2, mitochondrial|thioredoxin reductase 3|thioredoxin reductase TR3|thioredoxin reductase beta |
| Swissprots | Q9NZV3 Q9UQU8 O95840 Q96IJ2 Q9NNW7 Q9H2Z5 Q9P2Y0 Q9P2Y1 Q9NZV4 |
| Accessions | Q9NNW7 AB019694 BAA77601 AB019695 BAA77602 AB209724 BAD92961 AF044212 AAD25167 AF106697 AAD19597 AF166126 AAF21431 AF166127 AAF21432 AF171054 AAD51324 AF201385 AAG47635 AK094698 AK097708 BAG53517 BC007489 AAH07489 BC032029 BC038708 BC099923 AAH99923 BC117354 AAI17355 BX957216 CAF29507 CR749428 CAH18266 R46611 NM_001282512 NP_001269441 NM_006440 NP_006431 NM_145747 NM_145748 |
| Function | Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:10215850}. |
| Tissue Specificity | Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. {ECO:0000269|PubMed:10215850, ECO:0000269|PubMed:10608886, ECO:0000269|PubMed:9923614}. |
| Top Pathways | Selenocompound metabolism, Pyrimidine metabolism |