TXNRD2

Gene Symbol	TXNRD2
Entrez Gene	10587
Alt Symbol	SELZ, TR, TR-BETA, TR3, TRXR2
Species	Human
Gene Type	protein-coding
Description	thioredoxin reductase 2
Other Description	selenoprotein Z\|thioredoxin reductase 2, mitochondrial\|thioredoxin reductase 3\|thioredoxin reductase TR3\|thioredoxin reductase beta
Swissprots	Q9NZV3 Q9UQU8 O95840 Q96IJ2 Q9NNW7 Q9H2Z5 Q9P2Y0 Q9P2Y1 Q9NZV4
Accessions	Q9NNW7 AB019694 BAA77601 AB019695 BAA77602 AB209724 BAD92961 AF044212 AAD25167 AF106697 AAD19597 AF166126 AAF21431 AF166127 AAF21432 AF171054 AAD51324 AF201385 AAG47635 AK094698 AK097708 BAG53517 BC007489 AAH07489 BC032029 BC038708 BC099923 AAH99923 BC117354 AAI17355 BX957216 CAF29507 CR749428 CAH18266 R46611 NM_001282512 NP_001269441 NM_006440 NP_006431 NM_145747 NM_145748
Function	Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:10215850}.
Tissue Specificity	Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. {ECO:0000269\|PubMed:10215850, ECO:0000269\|PubMed:10608886, ECO:0000269\|PubMed:9923614}.
Top Pathways	Selenocompound metabolism, Pyrimidine metabolism

TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb - 12029 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Mouse
Clonality	Monoclonal
Clone	3F2-E12-F10

Western blot analysis of extracts from various cell lines using TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb.

TrxR2 (B-10) - sc-365714 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

TrxR2 (B-10): sc-365714. Western blot analysis of TrxR2 expression in HeLa whole cell lysate.

TrxR2 (D-12) - sc-166259 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

TrxR2 (D-12): sc-166259. Western blot analysis of TrxR2 expression in HeLa whole cell lysate.

TrxR2 (H-55) - sc-67126 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

TrxR2 (H-55): sc-67126. Western blot analysis of TrxR2 expression in non-transfected: sc-117752 (A) and mouse TrxR2 transfected: sc-124315 (B) 293T whole cell lysates.

TrxR2 (N-12) - sc-46278 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TrxR2 (N-12): sc-46278. Western blot analysis of TrxR2 expression in HeLa (A), K-562 (B), Hep G2 (C), Caki-1 (D), SW480 (E) and A-431 (F) whole cell lysates.

TrxR2 (N-13) - sc-46279 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TrxR2 (N-13): sc-46279. Western blot analysis of TrxR2 expression in HeLa (A), K-562 (B) and Hep G2 (C) whole cell lysates and mouse heart tissue extract (D).

Anti-TXNRD2 antibody - ab58445 from Abcam

Prices	$398.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

1/50 ab58445 staining paraffin-embedded human breast carcinoma tissue by Immunohistochemistry with and without blocking peptide.

Anti-TXNRD2 antibody - ab195745 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TXNRD2 antibody (ab195745) at 1/500 dilution + HeLa lysate at 35 µgSecondarygoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-TXNRD2 antibody - ab16841 from Abcam

Prices	$387.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-TXNRD2 antibody (ab16841) at 1/2000 dilutionLane 1 : Jurkat lysateLane 2 : Mouse liver lysateLane 3 : Rat lung lysate

Anti-TXNRD2 antibody - ab151486 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TXNRD2 antibody (ab151486) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-TXNRD2 antibody - ab15173 from Abcam

Prices	$370.00
Sizes	500 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TXNRD2 antibody - ab94522 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-TXNRD2 antibody (ab94522) at 1 µg/mlLane 1 : Prostate (Human) Whole Cell Lysate - liver cirrhosis (ab30307)Lane 2 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 3 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TXNRD2 antibody [25B3] - ab16852 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	25B3

Immunoprecipitation analysis of HeLa cell lysates using ab16852.Lane 1: Input.Lane 2: Precipitates. Reprobing was done with ab16841.

Anti-TXNRD2 antibody [3F2-E12-F10] - ab150758 from Abcam

Host	Mouse
Clonality	Monoclonal
Clone	3F2-E12-F10

All lanes : Anti-TXNRD2 antibody [3F2-E12-F10] (ab150758) at 1/1000 dilutionLane 1 : A431 cell lysatesLane 2 : U251 cell lysatesLane 3 : U2OS cell lysatesLane 4 : LNCAP cell lysatesLane 5 : HeLa cell lysates

Anti-TXNRD2 antibody [7B2] - ab16854 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	7B2

Immunoprecipitation analysis of HeLa cell lysates using ab16854.Lane 1: Input.Lane 2: Precipitates.

Anti-TXNRD2 antibody [EPR12480] - ab180493 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR12480

All lanes : Anti-TXNRD2 antibody [EPR12480] (ab180493) at 1/5000 dilutionLane 1 : Fetal liver lysateLane 2 : Fetal heart lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab136636) at 1/1000 dilution

Anti-TXNRD2 antibody [EPR12481] - ab181864 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR12481

All lanes : Anti-TXNRD2 antibody [EPR12481] (ab181864) at 1/1000 dilutionLane 1 : A431 cell lysateLane 2 : HepG2 cell lysateLane 3 : LnCaP cell lysateLane 4 : HeLa cell lysateLysates/proteins at 20 µg per lane.Secondarygoat anti-rabbit IgG, (H+L), peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-TXNRD2 antibody, prediluted - ab15174 from Abcam

Prices	$370.00
Sizes	7 ml
Host	Rabbit
Clonality	Polyclonal

Anti-TXNRD2 Antibody - LS-C132427 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-TXNRD2 Antibody (C-Terminus) - LS-C50627 from LifeSpan Bioscience

Prices	$440.00
Sizes	250 µl
Host	Rabbit
Clonality	Polyclonal

Liver carcinoma stained with Anti-TrxR2 antibody

Anti-TXNRD2 Antibody - LS-C132428 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-TXNRD2 Antibody - LS-C62197 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TXNRD2 Antibody (C-Terminus) - LS-C189255 from LifeSpan Bioscience

Prices	$425.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TXNRD2 Antibody - LS-C61908 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal

Anti-TXNRD2 Antibody - LS-C189904 from LifeSpan Bioscience

Prices	$445.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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