Gene Symbol |
SLC35C2
|
Entrez Gene |
51006
|
Alt Symbol |
BA394O2.1, C20orf5, CGI-15, OVCOV1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
solute carrier family 35 (GDP-fucose transporter), member C2
|
Other Description |
ovarian cancer-overexpressed gene 1 protein|solute carrier family 35 member C2
|
Swissprots |
Q9Y304 Q96CJ8 B7Z6V6 Q9NQQ7 Q53GK3 E1P5T0 Q5JW05
|
Accessions |
EAW75747 EAW75748 EAW75749 EAW75750 EAW75751 EAW75752 EAW75753 Q9NQQ7 AF132949 AAD27724 AF455052 AAL59605 AK094358 AK128842 AK222928 BAD96648 AK300207 BAH13238 AK300798 BAH13350 AK301022 BAH13392 AK315726 AW275152 BC014191 AAH14191 BC021138 AAH21138 BC025277 AAH25277 BI831689 BM666377 BM846744 DA820126 DB023133 DB246755 DQ891894 ABM82820 DQ896837 ABM87836 XM_011528831 XP_011527133 XM_011528832 XP_011527134 XM_011528833 XP_011527135 XM_011528834 XP_011527136 XM_011528835 XP_011527137 XM_011528836 XP_011527138 XM_011528837 XP_011527139 XM_011528838 XP_011527140 XR_936541 XR_936543 NM_001281457 NP_001268386 NM_001281458 NP_001268387 NM_001281459 NP_001268388 NM_001281460 NP_001268389 NM_015945 NP_057029 NM_173073 NP_775096 NM_173179 NP_775271
|
Function |
May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. {ECO:0000269|PubMed:20837470}.
|
Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:20837470}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:20837470}.
|
Tissue Specificity |
Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.
|