| Gene Symbol |
Prc1
|
| Entrez Gene |
233406
|
| Alt Symbol |
D7Ertd348e
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
protein regulator of cytokinesis 1
|
| Other Description |
prc1
|
| Swissprots |
Q99K43 Q8CE25 E9QPF0
|
| Accessions |
EDL07012 EDL07013 EDL07014 EDL07015 EDL07016 Q99K43 AF408435 AAL11727 AK029140 BAC26320 AK081506 AK088576 AK135778 AK190153 BC005475 AAH05475 BC059808 CF736005 XM_006540855 XP_006540918 XM_006540856 XP_006540919 XM_006540857 XP_006540920 NM_001285997 NP_001272926 NM_001285998 NP_001272927 NM_145150 NP_660132
|
| Function |
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles, and localizes with the cell midbody during cytokinesis (By similarity). {ECO:0000250}.
|
