| Gene Symbol |
PACS1
|
| Entrez Gene |
55690
|
| Alt Symbol |
MRD17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphofurin acidic cluster sorting protein 1
|
| Other Description |
PACS-1|cytosolic sorting protein PACS-1
|
| Swissprots |
Q96MW0 Q8N8K6 Q6PKB6 Q6VY07 Q6PJY6 Q9NW92 Q7Z590 Q7Z5W4 Q9ULP5
|
| Accessions |
EAW74502 EAW74503 EAW74504 EAW74505 EAW74506 Q6VY07 AB033001 BAA86489 AK001071 BAA91491 AK056361 BAB71164 AK096644 BAC04831 AK098336 AK293966 BAG57338 AL137271 CAB70669 AY320283 AAQ67682 BC003173 AAH03173 BC009936 AAH09936 BC010096 AAH10096 BC042909 BC052577 AAH52577 BC055288 AAH55288 BQ772654 XM_011545162 XP_011543464 XM_011545163 XP_011543465 XM_011545164 XP_011543466 NM_018026 NP_060496
|
| Function |
Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. {ECO:0000269|PubMed:11331585}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Localizes in the perinuclear region, probably the TGN. {ECO:0000250}.
|