FGF2

Gene Symbol FGF2
Entrez Gene 281161
Alt Symbol FGF-2
Species Bovine
Gene Type protein-coding
Description fibroblast growth factor 2 (basic)
Other Description BFGF|HBGF-2|basic fibroblast growth factor|fibroblast growth factor 2|heparin-binding growth factor 2
Swissprots P03969
Accessions CAH18496 CAH23438 CAI38633 DAA20823 P03969 CB165588 M13440 AAA30518 NM_174056 NP_776481
Function Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity). {ECO:0000250}.
Subcellular Location Secreted {ECO:0000250}. Nucleus {ECO:0000250}. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity). {ECO:0000250}.
Top Pathways Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

FGF basic/FGF2 Antibody - NB600-1536 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: FGF basic/FGF2 Antibody [NB600-1536] - Immunoperoxidase staining (PAP) of U87MG glioma cell suspension implanted into nude rat brain (Han rnu/rnu) using Rabbit Anti-Fibroblast Growth Factor-Basic (NB600-1536). High bFGF expression is exclusively shown within tumor endothelial cells. The tissue sample was paraffin-embedded and 4% Tris-buffered formalin-fixed without any enzymatic or antigen-demasking pre-processing. From Dr. A.-C. Stan, Institute of Neuropathology, Medical School Hannover, Hannover, Germany. Ref: Stan, A.C., et al., J. Neurosurg., 82, 1044 (1995).

FGF basic/FGF2 Antibody - AB-33-NA from Novus Biologicals

Prices $399.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal
Bovine FGF basic (Catalog # 133-FB) stimulates proliferation in the NR6R‑3T3 mouse fibroblast cell line in a dose-dependent manner (orange line). Proliferation elicited by Bovine FGF basic (0.5 ng/mL) is neutralized (green line) by increasing concentrations of Rabbit Anti-Bovine FGF basic Polyclonal Antibody (Catalog # AB-33-NA). The ND50 is typically 1.5-4.5 µg/mL.

Anti-Fibroblast Growth Factor-Basic antibody produced in goat - F5180 from Sigma-Aldrich

Prices $424.50
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit - F3393 from Sigma-Aldrich

Prices $148.50, $595.00
Sizes 100 µl, f3393-5x.1ml
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemisrty</B><BR/>Immunoperoxidase staining (PAP) of U87MG glioma cell suspension implanted into nude rat brain (Han rnu/rnu) using Rabbit Anti-Fibroblast Growth Factor-Basic (<B>Cat. No. F3393</B>). High bFGF expression is exclusively shown within tumor endothelial cells. The tissue sample was paraffin-embedded and 4% Tris-buffered formalin-fixed without any enzymatic or antigen-demasking pre-processing.<BR/>From Dr. A.-C. Stan, Institute of Neuropathology, Medical School Hannover, Hannover, Germany. Ref: Stan, A.C., et al., J. Neurosurg., <B>82</B>, 1044 (1995).

Monoclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) - MAA551Bo21 from Cloud-clone

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) - PAA551Bo01 from Cloud-clone

Host Rabbit
Clonality Polyclonal
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