Gene Symbol | GTF2H2C |
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Entrez Gene | 728340 |
Alt Symbol | GTF2H2C_2 |
Species | Human |
Gene Type | protein-coding |
Description | GTF2H2 family member C |
Other Description | general transcription factor IIH polypeptide 2-like protein|general transcription factor IIH subunit 2-like protein|general transcription factor IIH, polypeptide 2C |
Swissprots | Q15571 Q13888 Q9BS41 Q15570 |
Accessions | Q6P1K8 AK292361 BAF85050 AK315282 BAG37691 BC105980 AAI05981 BC157894 BC171860 AAI71860 DQ786295 XM_005248588 XP_005248645 XM_005248590 XP_005248647 XM_005248591 XP_005248648 XM_005248592 XP_005248649 XM_005248593 XP_005248650 XM_005276784 XP_005276841 XM_005276786 XP_005276843 XM_005276787 XP_005276844 XM_005276788 XP_005276845 XM_005276789 XP_005276846 XM_006714688 XP_006714751 XM_006714689 XP_006714752 XM_006726217 XP_006726280 XM_011543615 XP_011541917 XM_011546961 XP_011545263 XM_011546962 XP_011545264 NM_001098728 NP_001092198 |
Function | Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter. |
Subcellular Location | Nucleus. |
Tissue Specificity | Widely expressed, with higher expression in skeletal muscle. |
Top Pathways | Nucleotide excision repair, Viral carcinogenesis, Basal transcription factors |
TFIIH 2C CRISPR/Cas9 KO Plasmid (h) - sc-418539 from Santa Cruz Biotechnology
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TFIIH 2C HDR Plasmid (h) - sc-418539-HDR from Santa Cruz Biotechnology
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TFIIH 2C Double Nickase Plasmid (h) - sc-418539-NIC from Santa Cruz Biotechnology
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TFIIH 2C Double Nickase Plasmid (h2) - sc-418539-NIC-2 from Santa Cruz Biotechnology
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TFIIH 2C CRISPR Activation Plasmid (h) - sc-418539-ACT from Santa Cruz Biotechnology
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TFIIH 2C CRISPR Activation Plasmid (h2) - sc-418539-ACT-2 from Santa Cruz Biotechnology
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TFIIH 2C Lentiviral Activation Particles (h) - sc-418539-LAC from Santa Cruz Biotechnology
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TFIIH 2C Lentiviral Activation Particles (h2) - sc-418539-LAC-2 from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN9764 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9764 from Sigma-Aldrich
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GTF2H2C siRNA (Human) - CRJ8658 from Cohesion Biosciences
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shRNA set against Human GTF2H2C (NM_001098728.1) - SHH308946 from Creative biogene
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Human GTF2H2C siRNA - orb279159 from Biorbyt
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GTF2H2C shRNA Plasmid (Human) - CHJ8658 from Cohesion Biosciences
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GTF2H2C miRNA 3'UTR clone - MiUTR3H-15055 from Creative biogene
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