| Gene Symbol | ADRA2B |
|---|---|
| Entrez Gene | 151 |
| Alt Symbol | ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR |
| Species | Human |
| Gene Type | protein-coding |
| Description | adrenoceptor alpha 2B |
| Other Description | ADRA2B adrenergic, alpha-2B-, receptor|G-protein coupled receptor|alpha-2 adrenergic receptor subtype C2|alpha-2-adrenergic receptor-like 1|alpha-2B adrenergic receptor|alpha-2B adrenoreceptor |
| Swissprots | Q9BZK0 Q4TUH9 P18089 Q53RF2 |
| Accessions | AAA51666 AAA62823 AAB62558 AAK01635 AAS55646 AAX93218 AAY43127 ABY87536 EAW71390 P18089 AA887330 BC133021 AAI33022 BC136537 AAI36538 BF475329 CV806541 NM_000682 NP_000673 |
| Function | Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. {ECO:0000269|PubMed:23105096}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:23105096}; Multi-pass membrane protein {ECO:0000269|PubMed:23105096}. Note=Interaction with RAB26 mediates transport from the Golgi to the cell membrane. |
| Top Pathways | cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction |