| Gene Symbol |
ADRA2B
|
| Entrez Gene |
151
|
| Alt Symbol |
ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adrenoceptor alpha 2B
|
| Other Description |
ADRA2B adrenergic, alpha-2B-, receptor|G-protein coupled receptor|alpha-2 adrenergic receptor subtype C2|alpha-2-adrenergic receptor-like 1|alpha-2B adrenergic receptor|alpha-2B adrenoreceptor
|
| Swissprots |
Q9BZK0 Q4TUH9 P18089 Q53RF2
|
| Accessions |
AAA51666 AAA62823 AAB62558 AAK01635 AAS55646 AAX93218 AAY43127 ABY87536 EAW71390 P18089 AA887330 BC133021 AAI33022 BC136537 AAI36538 BF475329 CV806541 NM_000682 NP_000673
|
| Function |
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. {ECO:0000269|PubMed:23105096}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23105096}; Multi-pass membrane protein {ECO:0000269|PubMed:23105096}. Note=Interaction with RAB26 mediates transport from the Golgi to the cell membrane.
|
| Top Pathways |
cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction
|