| Gene Symbol |
Trpv1
|
| Entrez Gene |
83810
|
| Alt Symbol |
TRPV1_SON, VR.5'sv, Vr1, Vr1l1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily V, member 1
|
| Other Description |
OTRPC1|capsaicin receptor|osm-9-like TRP channel 1|transient receptor potential cation channel subfamily V member 1|transient receptor potential vanilloid 1 supraoptic nucleus|vanilloid receptor 1|vanilloid receptor subtype 1|vanilloid receptor type 1 like protein 1|vanilloid type 1 receptor
|
| Swissprots |
Q920B3 O35433 Q9JM57 Q9JM56 Q920B4 Q9JLM0
|
| Accessions |
AAK83151 AAK83152 EDM05146 O35433 AB015231 BAA34942 AB040873 BAA94307 AB041029 BAA94306 AF029310 AAC53398 AF158248 AAF28389 LC008303 BAP90828 XM_008767882 XP_008766104 NM_031982 NP_114188
|
| Function |
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depre
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines.
|
| Tissue Specificity |
Predominantly expressed in trigeminal and dorsal root sensory ganglia. Expressed also in hippocampus, cortex, cerebellum, olfactory bulb, mesencephalon and hindbrain. High expression in the cell bodies and dendrites of neurons in the hippocampus and in the cortex. In the brain detected also in astrocytes and pericytes. Isoform 1 and isoform 3 are expressed in brain and peripheral blood mononuclear cells. {ECO:0000269|PubMed:10644739, ECO:0000269|PubMed:15857679, ECO:0000269|PubMed:9349813}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction
|