Ctnnb1

Gene Symbol	Ctnnb1
Entrez Gene	12387
Alt Symbol	Bfc, Catnb, Mesc
Species	Mouse
Gene Type	protein-coding
Description	catenin (cadherin associated protein), beta 1
Other Description	beta-catenin|catenin beta-1
Swissprots	Q02248 Q9D335 Q922W1
Accessions	EDL09164 EDL09165 EDL09166 Q02248 AK018515 BAB31250 AK020013 AK035311 BAC29027 AK132398 AK133656 BAE21768 AK135743 AK178155 AK179148 AK179260 AK180997 AK184861 AK189807 AK190684 AK191852 AK196236 AK196547 AK197513 AK197664 AK197753 AK199952 AK201646 AK201809 AK202371 AK203436 AK203824 AK204053 AK208830 AK209047 AK209437 AK209908 AK210588 AK211747 AK214825 AK219273 AK219949 AY751549 BC006739 AAH06739 BC043078 BC043481 AAH43481 BC048153 AAH48153 BC053065 AAH53065 BY766878 M90364 AAA37280 NM_001165902 NP_001159374 NM_007614 NP_031640
Function	Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts w
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, adherens junction. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta- catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Colocalized with RAPGEF2
Top Pathways	Adherens junction, Proteoglycans in cancer, Rap1 signaling pathway, Tight junction, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® β-Catenin siRNA II (Mouse Specific) - 6388 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

SignalSilence ® β-Catenin siRNA I (Mouse Specific) - 6387 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

β-catenin siRNA (m) - sc-29210 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

β-catenin shRNA Plasmid (m) - sc-29210-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

β-catenin shRNA (m) Lentiviral Particles - sc-29210-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

β-catenin siRNA (m2) - sc-44253 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

β-catenin shRNA Plasmid (m2) - sc-44253-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

β-catenin shRNA (m2) Lentiviral Particles - sc-44253-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU047621 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN29366 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29366 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CTNNB1 siRNA (Mouse) - CRM0520 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

CTNNB1 - MBS8240841 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse CTNNB1 (NM_007614.3) - SHH271313 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse CTNNB1 siRNA - orb279996 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

CTNNB1 shRNA Plasmid (Mouse) - CHM0520 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

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