| Gene Symbol |
GDI1
|
| Entrez Gene |
2664
|
| Alt Symbol |
1A, GDIL, MRX41, MRX48, OPHN2, RABGD1A, RABGDIA, XAP-4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GDP dissociation inhibitor 1
|
| Other Description |
GDI-1|guanosine diphosphate dissociation inhibitor 1|mental retardation, X-linked 48|oligophrenin-2|protein XAP-4|rab GDI alpha|rab GDP dissociation inhibitor alpha|rab GDP-dissociation inhibitor, alpha
|
| Swissprots |
Q7Z2I6 Q7Z2H5 P50394 Q7Z2G6 Q7Z2G9 Q6FG50 P31150
|
| Accessions |
AAA21558 AAA92648 BAC80330 BAC80331 BAC80332 BAC80333 BAC80334 BAC80335 BAC80336 BAC80337 BAC80338 BAC80339 BAC80340 BAC80341 BAC80342 BAC80343 BAC80344 BAC80345 BAC80346 BAC80347 BAC80348 BAC80349 BAC80360 BAC80361 BAC80362 BAC80363 BAC80364 BAC80365 BAC80366 BAC80367 BAC80368 BAC80369 BAC80370 BAC80371 BAC80372 BAC80373 BAC80374 BAC80375 BAC80376 BAC80377 BAC80378 BAC80379 BAC80390 BAC80391 BAC80392 BAC80393 BAC80394 BAC80395 BAC80396 BAC80397 BAC80398 BAC80399 BAC80400 BAC80401 BAC80402 BAC80403 BAC80404 BAC80405 BAC80406 BAC80407 BAC80408 BAC80409 BAC80420 BAC80421 BAC80422 BAC80423 BAC80424 BAC80425 BAC80426 BAC80427 BAC80428 BAC80429 BAC80430 BAC80431 BAC80432 BAC80433 BAC80434 BAC80435 BAC80436 BAC80437 BAC80438 BAC80439 CAA55909 CCQ43142 EAW72709 EAW72710 EAW72711 P31150 AB102647 BAC81116 AF400433 AAK92482 AK090746 AK123405 AK131466 AK294893 BAG57985 AK295306 BAG58286 AK303248 BAG64332 AL833629 AM392660 CAL37538 AM393226 CAL38104 AM393601 CAL38477 BC000317 AAH00317 BC012201 AAH12201 BT019884 AAV38687 CR542258 CAG47054 CR542276 CAG47072 D45021 BAA08078 DA133083 DB005169 DQ892049 ABM82975 DQ895243 ABM86169 DQ896843 ABM87842 EF212243 EF212248 L05086 AAC15851 X74608 X79353 CAA55908 X87194 NM_001493 NP_001484
|
| Function |
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:23815289}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19570034}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19570034}.
|
| Tissue Specificity |
Brain; predominant in neural and sensory tissues. {ECO:0000269|PubMed:7543319}.
|
![Western Blot: GDI1 Overexpression Lysate (Adult Normal) [NBL1-11029] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GDI1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/916_GDI1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11029-img0002.jpg)