| Gene Symbol | D-AKAP2 |
|---|---|
| Entrez Gene | 397262 |
| Alt Symbol | Akap10 |
| Species | Pig |
| Gene Type | protein-coding |
| Description | protein kinase A anchoring protein |
| Other Description | A kinase anchor protein 10, mitochondrial|A-kinase anchor protein 10, mitochondrial|AKAP-10|D-AKAP-2|PRKA10|dual specificity A kinase-anchoring protein 2|protein kinase A-anchoring protein 10 |
| Swissprots | P57770 |
| Accessions | P57770 AF208387 AAG35731 NM_214138 NP_999303 |
| Function | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic. {ECO:0000250}. |