| Gene Symbol |
D-AKAP2
|
| Entrez Gene |
397262
|
| Alt Symbol |
Akap10
|
| Species |
Pig
|
| Gene Type |
protein-coding
|
| Description |
protein kinase A anchoring protein
|
| Other Description |
A kinase anchor protein 10, mitochondrial|A-kinase anchor protein 10, mitochondrial|AKAP-10|D-AKAP-2|PRKA10|dual specificity A kinase-anchoring protein 2|protein kinase A-anchoring protein 10
|
| Swissprots |
P57770
|
| Accessions |
P57770 AF208387 AAG35731 NM_214138 NP_999303
|
| Function |
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic. {ECO:0000250}.
|