| Gene Symbol |
KRT25
|
| Entrez Gene |
147183
|
| Alt Symbol |
KRT25A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin 25, type I
|
| Other Description |
CK-25|K25|K25A|cytokeratin-25|keratin 25A|keratin, type I cytoskeletal 25|keratin-25|keratin-25A|type I inner root sheath specific keratin 25 irs1|type I inner root sheath-specific keratin-K25irs1
|
| Swissprots |
Q7Z3Z0
|
| Accessions |
EAW60676 Q7Z3Z0 AJ564204 CAD91904 AK129503 BAC85169 BC140408 AAI40409 BC146488 AAI46489 XM_011524414 XP_011522716 NM_181534 NP_853512
|
| Function |
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). {ECO:0000250|UniProtKB:Q8VCW2}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:Q8VCW2}.
|
| Tissue Specificity |
Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level). {ECO:0000269|PubMed:15617563, ECO:0000269|PubMed:16874310}.
|