| Gene Symbol |
CMYA5
|
| Entrez Gene |
202333
|
| Alt Symbol |
C5orf10, SPRYD2, TRIM76
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cardiomyopathy associated 5
|
| Other Description |
2310076E16Rik|SPRY domain-containing protein 2|cardiomyopathy-associated protein 5|dystrobrevin-binding protein 2|genethonin-3|myospryn|tripartite motif-containing 76|tripartite motif-containing protein 76
|
| Swissprots |
Q69YQ9 Q6P5U3 Q05CT4 Q7Z4I1 Q2NKX1 Q86T49 Q8NAG8 Q9UK88 Q8N3S7 Q6P517 Q2T9G9 Q86T34 A0PJB7 Q69YQ8 Q8N3K9 Q8N3S4
|
| Accessions |
EAW95839 Q8N3K9 AF177292 AAD55265 AF533705 AAQ09018 AK092699 AK096453 AK123466 AL359338 AL831966 CAD38607 AL831968 CAD38609 AL831986 CAD91143 AL832021 AL832347 CAH10406 AL832368 CAD91158 AL832376 CAH10402 AL834252 CAD38928 BC020856 AAH20856 BC022422 AAH22422 BC022430 BC029434 BC046215 BC062664 AAH62664 BC063134 AAH63134 BC111529 AAI11530 BC111530 AAI11531 BX647452 BX647628 BX647646 XR_948242 NM_153610 NP_705838
|
| Function |
May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:20634290}. Note=Found predominantly at the periphery of the nucleus but also throughout the cell. Localized in lysosomes (By similarity). In skeletal muscles, localizes along myofiber periphery, at costameres (By similarity). Predominantly flanks Z-disks. Occasionnally present at the M-band level. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in skeletal muscle; at a strong level and in heart. {ECO:0000269|PubMed:11297942}.
|