RBPMS
| Gene Symbol | RBPMS |
|---|---|
| Entrez Gene | 11030 |
| Alt Symbol | HERMES |
| Species | Human |
| Gene Type | protein-coding |
| Description | RNA binding protein with multiple splicing |
| Other Description | RNA-binding protein with multiple splicing|heart and RRM expressed sequence |
| Swissprots | Q96J26 Q92518 Q93062 Q92517 D3DSU9 Q92516 |
| Accessions | EAW63451 EAW63453 EAW63454 EAW63459 EAW63460 EAW63461 EAW63462 Q93062 AI025136 AK024192 AK057533 AK098281 AK304858 BAG65596 AK310533 BC003608 AAH03608 BC063494 BC092476 AAH92476 BE733116 BG480355 BX097929 CA425568 CD518168 CN360712 CX165198 CX781149 D84107 BAA12225 D84108 BAA12226 D84109 BAA12227 D84110 BAA12228 D84111 BAA12229 N88549 XM_006716277 XP_006716340 XM_011544372 XP_011542674 XM_011544373 XP_011542675 XM_011544374 XP_011542676 XM_011544375 XP_011542677 XM_011544376 XP_011542678 XM_011544377 XP_011542679 XM_011544378 XP_011542680 XM_011544379 XP_011542681 XM_011544380 XP_011542682 XM_011544381 XP_011542683 XM_011544382 XP_011542684 NM_001008710 NP_001008710 NM_001008711 NP_001008711 NM_001008712 NP_001008712 NM_006867 NP_006858 |
| Function | Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. {ECO:0000269|PubMed:17099224}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:17099224}. Cytoplasm {ECO:0000269|PubMed:17099224}. |
| Tissue Specificity | Ubiquitously expressed, at various levels depending on the isoform and the tissue. |
RBPMS CRISPR/Cas9 KO Plasmid (h) - sc-403369 from Santa Cruz Biotechnology
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RBPMS HDR Plasmid (h) - sc-403369-HDR from Santa Cruz Biotechnology
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RBPMS Double Nickase Plasmid (h) - sc-403369-NIC from Santa Cruz Biotechnology
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RBPMS Double Nickase Plasmid (h2) - sc-403369-NIC-2 from Santa Cruz Biotechnology
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RBPMS CRISPR Activation Plasmid (h) - sc-403369-ACT from Santa Cruz Biotechnology
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RBPMS CRISPR Activation Plasmid (h2) - sc-403369-ACT-2 from Santa Cruz Biotechnology
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RBPMS Lentiviral Activation Particles (h) - sc-403369-LAC from Santa Cruz Biotechnology
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RBPMS Lentiviral Activation Particles (h2) - sc-403369-LAC-2 from Santa Cruz Biotechnology
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RBPMS siRNA (h) - sc-77460 from Santa Cruz Biotechnology
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RBPMS shRNA Plasmid (h) - sc-77460-SH from Santa Cruz Biotechnology
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RBPMS shRNA (h) Lentiviral Particles - sc-77460-V from Santa Cruz Biotechnology
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RBPMS RNAi - H00011030-R01 from Novus Biologicals
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RBPMS RNAi - H00011030-R02 from Novus Biologicals
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RBPMS RNAi - H00011030-R04 from Novus Biologicals
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RBPMS RNAi - H00011030-R03 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN18084 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18084 from Sigma-Aldrich
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RBPMS siRNA (Human) - CRH7537 from Cohesion Biosciences
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RBPMS - MBS8236301 from MyBioSource
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shRNA set against Human RBPMS (NM_006867.2) - SHH391124 from Creative biogene
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shRNA set against Human RBPMS(NM_001008711.1) - SHR172832 from Creative biogene
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shRNA set against Human RBPMS(NM_001008712.1) - SHR172858 from Creative biogene
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shRNA set against Human RBPMS(NM_001008710.1) - SHR172894 from Creative biogene
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shRNA set against Human RBPMS(NM_001008711.1) - SHR172948 from Creative biogene
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RBPMS shRNA Plasmid (Human) - CHH7537 from Cohesion Biosciences
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