Gene Symbol | Acsl1 |
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Entrez Gene | 14081 |
Alt Symbol | Acas, Acas1, Acs, FACS, Facl2, LACS 1, LACS1 |
Species | Mouse |
Gene Type | protein-coding |
Description | acyl-CoA synthetase long-chain family member 1 |
Other Description | acetate-CoA ligase|acetyl-CoA synthetase|acetyl-Coenzyme A synthetase 1 (ADP forming)|fatty acid Coenzyme A ligase, long chain 2|long-chain acyl-CoA synthetase 1|long-chain-fatty-acid--CoA ligase 1 |
Swissprots | Q6GTG6 Q9DBK5 P41216 |
Accessions | CBF65114 CBU89985 EDL35573 EDL35574 P41216 AK004897 BAB23652 AK145900 BAE26736 AK149406 BAE28854 AK152772 BAE31484 AK153050 BAE31678 AK158388 AK161189 BAE36230 AK168078 BAE40051 AK180785 AK216738 AK216933 BC006692 BC056644 AAH56644 BY094311 BY142492 BY393025 BY786934 U15977 AAA52193 XM_006509262 XP_006509325 XM_006509264 XP_006509327 XM_006509265 XP_006509328 XM_006509266 XP_006509329 NM_001302163 NP_001289092 NM_007981 NP_032007 |
Function | Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses oleate, arachidonate, eicosapentaenoate and docosahexaenoate as substrates (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. |
Top Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation |
ACSL1 CRISPR/Cas9 KO Plasmid (m) - sc-420278 from Santa Cruz Biotechnology
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ACSL1 HDR Plasmid (m) - sc-420278-HDR from Santa Cruz Biotechnology
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ACSL1 Double Nickase Plasmid (m) - sc-420278-NIC from Santa Cruz Biotechnology
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ACSL1 Double Nickase Plasmid (m2) - sc-420278-NIC-2 from Santa Cruz Biotechnology
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ACSL1 CRISPR Activation Plasmid (m) - sc-420278-ACT from Santa Cruz Biotechnology
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ACSL1 CRISPR Activation Plasmid (m2) - sc-420278-ACT-2 from Santa Cruz Biotechnology
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ACSL1 Lentiviral Activation Particles (m) - sc-420278-LAC from Santa Cruz Biotechnology
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ACSL1 Lentiviral Activation Particles (m2) - sc-420278-LAC-2 from Santa Cruz Biotechnology
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ACSL1 siRNA (m) - sc-60616 from Santa Cruz Biotechnology
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ACSL1 shRNA Plasmid (m) - sc-60616-SH from Santa Cruz Biotechnology
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ACSL1 shRNA (m) Lentiviral Particles - sc-60616-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU090901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26188 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26188 from Sigma-Aldrich
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ACSL1 siRNA (Mouse) - CRM1299 from Cohesion Biosciences
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ACSL1 - MBS8205333 from MyBioSource
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shRNA set against Mouse ACSL1 (NM_007981.3) - SHH230726 from Creative biogene
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shRNA set against Mouse Acsl1(NM_007981.3) - SHG035403 from Creative biogene
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Mouse ACSL1 siRNA - orb280775 from Biorbyt
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ACSL1 shRNA Plasmid (Mouse) - CHM1299 from Cohesion Biosciences
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ACSL1 miRNA 3'UTR clone - MiUTR1M-01133 from Creative biogene
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