| Gene Symbol |
LILRB1
|
| Entrez Gene |
10859
|
| Alt Symbol |
CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
|
| Other Description |
CD85 antigen-like family member J|Ig-like transcript 2|leukocyte immunoglobulin-like receptor subfamily B member 1|leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform|monocyte/macrophage immunoglobulin-like receptor 7
|
| Swissprots |
Q8NHK0 O75024 Q8NHL6 Q8NHJ9 O75025 A8MXT0 A2IXV4
|
| Accessions |
AAG08984 ADJ55944 ADJ55945 ADJ55946 ADJ55947 ADJ55948 ADJ55949 ADJ55950 ADJ55951 ADJ55952 CAM90892 EAW72266 EAW72267 EAW72268 EAW72269 Q8NHL6 AF009005 AAC51879 AF009006 AAC51880 AF009007 AAC51881 AF009220 AAB63521 AF009221 AAB63522 AF283984 AAL36988 AF283985 AAL36989 AK094834 AK223310 BAD97030 AK292028 BAF84717 AK292156 BAF84845 BC015731 AAH15731 DA263280 DA953794 DA991480 DQ892230 ABM83156 DQ895431 ABM86357 EU915608 ACK56074 U82279 AAC51179 XM_011526331 XP_011524633 XM_011526332 XP_011524634 XM_011526333 XP_011524635 XM_011526334 XP_011524636 XM_011526335 XP_011524637 XM_011526336 XP_011524638 XM_011526337 XP_011524639 XM_011526338 XP_011524640 XM_011526339 XP_011524641 XM_011547059 XP_011545361 XM_011547060 XP_011545362 XM_011547061 XP_011545363 XM_011547062 XP_011545364 XM_011547063 XP_011545365 XM_011547064 XP_011545366 XM_011547065 XP_011545367 XM_011547066 XP_011545368 XM_011547067 XP_011545369 XM_011547068 XP_011545370 XM_011547069 XP_011545371 XM_011547070 XP_011545372 XM_011548515 XP_011546817 XM_011548516 XP_011546818 XM_011548517 XP_011546819 XM_011548518 XP_011546820 XM_011548519 XP_011546821 XM_011548520 XP_011546822 XM_011548521 XP_011546823 XM_011548522 XP_011546824 XM_011548523 XP_011546825 XM_011548638 XP_011546940 XM_011548639 XP_011546941 XM_011548640 XP_011546942 XM_011548641 XP_011546943 XM_011548642 XP_011546944 XM_011548643 XP_011546945 XM_011548644 XP_011546946 XM_011548645 XP_011546947 XM_011548646 XP_011546948 XM_011548647 XP_011546949 XM_011548648 XP_011546950 XM_011548649 XP_011546951 XM_011548650 XP_011546952 XR_935716 XR_952183 XR_953122 XR_953163 NM_001081637 NP_001075106 NM_001081638 NP_001075107 NM_001081639 NP_001075108 NM_001278398 NP_001265327 NM_001278399 NP_001265328 NM_006669 NP_006660 NR_103518
|
| Function |
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells. {ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}.
|
| Top Pathways |
Osteoclast differentiation
|
![Western Blot: LILRB1 Overexpression Lysate (Adult Normal) [NBP2-07594] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LILRB1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10130_LILRB1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07594-img0001.jpg)