| Gene Symbol | LTA4H |
|---|---|
| Entrez Gene | 4048 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | leukotriene A4 hydrolase |
| Other Description | LTA-4 hydrolase|leukotriene A-4 hydrolase |
| Swissprots | B4DNQ9 F8VV40 Q6IAT6 P09960 Q9UCT7 |
| Accessions | AAA89077 AAC24315 EAW97557 EAW97558 EAW97559 EAW97560 P09960 AB209740 BAD92977 AK293630 BAG57086 AK298017 BAG60321 AK301308 BAG62860 AK308184 AK310461 AK310522 BC032528 AAH32528 BC036555 AAH36555 BX647158 CR457068 CAG33349 DB019628 DC358373 J02959 AAA36177 J03459 AAA36176 JF432734 ADZ15951 R41544 XM_005268871 XP_005268928 XM_011538348 XP_011536650 XM_011538349 XP_011536651 NM_000895 NP_000886 NM_001256643 NP_001243572 NM_001256644 NP_001243573 |
| Function | Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:2244921}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts. |
| Top Pathways | Arachidonic acid metabolism |