| Gene Symbol |
FURIN
|
| Entrez Gene |
281374
|
| Alt Symbol |
PACE
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
furin (paired basic amino acid cleaving enzyme)
|
| Other Description |
dibasic-processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid cleaving enzyme|paired basic amino acid residue-cleaving enzyme|trans Golgi network protease furin
|
| Swissprots |
Q28193
|
| Accessions |
DAA17642 Q28193 BC151596 AAI51597 JF919674 AFI43812 X75956 CAA53569 NM_174136 NP_776561
|
| Function |
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
|
| Tissue Specificity |
Seems to be expressed ubiquitously.
|
| Top Pathways |
Influenza A
|