| Gene Symbol | FURIN |
|---|---|
| Entrez Gene | 281374 |
| Alt Symbol | PACE |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | furin (paired basic amino acid cleaving enzyme) |
| Other Description | dibasic-processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid cleaving enzyme|paired basic amino acid residue-cleaving enzyme|trans Golgi network protease furin |
| Swissprots | Q28193 |
| Accessions | DAA17642 Q28193 BC151596 AAI51597 JF919674 AFI43812 X75956 CAA53569 NM_174136 NP_776561 |
| Function | Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. |
| Subcellular Location | Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin. |
| Tissue Specificity | Seems to be expressed ubiquitously. |
| Top Pathways | Influenza A |