| Gene Symbol |
ACACA
|
| Entrez Gene |
31
|
| Alt Symbol |
ACAC, ACACAD, ACC, ACC1, ACCA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acetyl-CoA carboxylase alpha
|
| Other Description |
ACC-alpha|acetyl-CoA carboxylase 1|acetyl-Coenzyme A carboxylase alpha
|
| Swissprots |
Q86WB3 Q7Z563 Q6XDA8 Q7Z561 Q7Z564 B2RP68 Q7Z2G8 Q13085 Q86WB2 Q6KEV6
|
| Accessions |
AAP94113 EAW57576 EAW57577 EAW57578 EAW57579 EAW57580 EAW57581 EAW57582 EAW57583 Q13085 AB209325 BAD92562 AB371587 BAG48316 AJ534888 CAD59556 AJ534889 CAD59557 AJ564444 CAD92089 AK129523 AK295586 BAG58478 AK295735 BAG58574 AK295805 BAG58623 AK296368 BAG59043 AK301579 BAG63071 AK308905 AK309084 AK309424 AK311329 AY237919 AAP69841 AY315619 AAP94114 AY315620 AAP94115 AY315621 AAP94116 AY315622 AAP94117 AY315623 AAP94118 AY315624 AAP94119 AY315625 AAP94120 AY315626 AAP94121 AY315627 AAP94122 BC031485 AAH31485 BC041598 BC137287 AAI37288 BF154865 CF454424 U19822 AAC50139 XM_005257267 XP_005257324 XM_006721853 XP_006721916 XM_006725320 XP_006725383 XM_011524701 XP_011523003 XM_011524702 XP_011523004 XM_011524703 XP_011523005 XM_011524704 XP_011523006 XM_011546805 XP_011545107 XM_011546806 XP_011545108 XM_011546807 XP_011545109 XM_011546808 XP_011545110 XR_934449 XR_951959 NM_198834 NP_942131 NM_198836 NP_942133 NM_198837 NP_942134 NM_198838 NP_942135 NM_198839 NP_942136 NM_000664 NM_198835
|
| Function |
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. {ECO:0000269|PubMed:20952656}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
|
| Top Pathways |
Insulin signaling pathway, AMPK signaling pathway, Glucagon signaling pathway, Fatty acid biosynthesis, Pyruvate metabolism
|