ATF2

Gene Symbol	ATF2
Entrez Gene	1386
Alt Symbol	CRE-BP1, CREB-2, CREB2, HB16, TREB7
Species	Human
Gene Type	protein-coding
Description	activating transcription factor 2
Other Description	activating transcription factor 2 splice variant ATF2-var2|cAMP response element-binding protein CRE-BP1|cAMP responsive element binding protein 2, formerly|cAMP-dependent transcription factor ATF-2|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-2|cyclic AMP-responsive element-binding protein 2|histone acetyltransferase ATF2
Swissprots	A1L3Z2 A4D7V1 D3DPE9 Q8TAR1 A4D7U5 Q53RY2 Q96JT8 P15336 Q13000 G8JLM5 A4D7U4 Q3B7B7 Q4ZFU9
Accessions	AAX88876 AAY15004 EAX11109 EAX11110 EAX11111 EAX11112 EAX11113 P15336 AF283776 AI200584 AK128731 BAG54719 AL050192 AY029364 AAK55760 BC026175 AAH26175 BC107698 AAI07699 BC130335 AAI30336 BC130337 AAI30338 BX648469 DA995464 DQ003036 AAY17202 DQ003037 AAY17203 DQ003038 AAY17204 DQ003039 AAY17205 DQ003040 AAY17206 DQ003041 AAY17207 DQ003042 AAY17208 DQ003043 AAY17209 DQ003044 AAY17210 DQ003045 AAY17211 DQ003046 AAY17212 DQ003047 AAY17213 DQ003048 AAY17214 DQ003049 AAY17215 HQ258270 ADR83024 M31630 AAA35951 X15875 CAA33886 NM_001256090 NP_001243019 NM_001256091 NP_001243020 NM_001256092 NP_001243021 NM_001256093 NP_001243022 NM_001256094 NP_001243023 NM_001880 NP_001871 NR_045768 NR_045769 NR_045770 NR_045771 NR_045772 NR_045773 NR_045774
Function	Transcriptional activator which regulates the transcription of various genes, including those involved in anti- apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF).
Subcellular Location	Nucleus. Cytoplasm. Mitochondrion outer membrane. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co- localizes with the MRN complex in the IR-induced foci (IRIF).
Tissue Specificity	Ubiquitously expressed, with more abundant expression in the brain.
Top Pathways	Estrogen signaling pathway, MAPK signaling pathway, Glucagon signaling pathway, Thyroid hormone synthesis, cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® ATF-2 siRNA I - 6433 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® ATF-2 siRNA II - 6443 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

ATF-2 CRISPR/Cas9 KO Plasmid (h) - sc-416662 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ATF-2 HDR Plasmid (h) - sc-416662-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATF-2 Double Nickase Plasmid (h) - sc-416662-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATF-2 Double Nickase Plasmid (h2) - sc-416662-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATF-2 CRISPR Activation Plasmid (h) - sc-416662-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ATF-2 CRISPR Activation Plasmid (h2) - sc-416662-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ATF-2 Lentiviral Activation Particles (h) - sc-416662-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATF-2 Lentiviral Activation Particles (h2) - sc-416662-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATF-2 siRNA (h) - sc-29205 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ATF-2 shRNA Plasmid (h) - sc-29205-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ATF-2 shRNA (h) Lentiviral Particles - sc-29205-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU125521 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3634 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3634 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02169 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02169

ATF2 siRNA (Human) - CRH0972 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATF2 RNAi - H00001386-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ATF2 - MBS8227872 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ATF2 (NM_001880.3) - SHH241906 from Creative biogene Category siRNA Species Reactivities Human

Human ATF2 siRNA - orb261474 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATF2 shRNA Plasmid (Human) - CHH0972 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ATF2 miRNA 3'UTR clone - MiUTR3H-00560 from Creative biogene Species Reactivities Human

Search more