Gene Symbol | COL22A1 |
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Entrez Gene | 169044 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | collagen, type XXII, alpha 1 |
Other Description | collagen alpha-1(XXII) chain |
Swissprots | Q8IVT9 C9K0G4 B7ZMH0 Q8NFW1 |
Accessions | CCQ43871 EAW92193 EAW92194 EAW92195 Q8NFW1 AA781676 AF406780 AAN03620 BC042075 AAH42075 BC144535 AAI44536 BC172420 AAI72420 BX094632 XM_011516883 XP_011515185 XM_011516884 XP_011515186 XM_011516885 XP_011515187 XM_011516886 XP_011515188 XM_011516887 XP_011515189 XM_011516888 XP_011515190 XM_011516889 XP_011515191 XM_011516890 XP_011515192 XM_011516891 XP_011515193 NM_152888 NP_690848 |
Function | Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. Cytoplasm {ECO:0000250}. |
Tissue Specificity | Restrictive expression is observed at tissue junctions such as the myotendinous junction in skeletal and heart muscle, the articular cartilage-synovial fluid junction, or the border between the anagen hair follicle and the dermis in the skin. It is deposited in the basement membrane zone of the myotendinous junction and the hair follicle and associated with the extrafibrillar matrix in cartilage. {ECO:0000269|PubMed:15016833}. |
Top Pathways | Protein digestion and absorption |
COL22A1 CRISPR/Cas9 KO Plasmid (h) - sc-406585 from Santa Cruz Biotechnology
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COL22A1 HDR Plasmid (h) - sc-406585-HDR from Santa Cruz Biotechnology
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COL22A1 Double Nickase Plasmid (h) - sc-406585-NIC from Santa Cruz Biotechnology
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COL22A1 Double Nickase Plasmid (h2) - sc-406585-NIC-2 from Santa Cruz Biotechnology
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COL22A1 CRISPR Activation Plasmid (h) - sc-406585-ACT from Santa Cruz Biotechnology
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COL22A1 CRISPR Activation Plasmid (h2) - sc-406585-ACT-2 from Santa Cruz Biotechnology
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COL22A1 Lentiviral Activation Particles (h) - sc-406585-LAC from Santa Cruz Biotechnology
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COL22A1 Lentiviral Activation Particles (h2) - sc-406585-LAC-2 from Santa Cruz Biotechnology
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COL22A1 siRNA (h) - sc-77503 from Santa Cruz Biotechnology
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COL22A1 shRNA Plasmid (h) - sc-77503-SH from Santa Cruz Biotechnology
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COL22A1 shRNA (h) Lentiviral Particles - sc-77503-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN6381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6381 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08090 from Sigma-Aldrich
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COL22A1 siRNA (Human) - CRJ6082 from Cohesion Biosciences
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COL22A1 - MBS8215710 from MyBioSource
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shRNA set against Human COL22A1 (NM_152888.1) - SHH267177 from Creative biogene
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COL22A1 shRNA Plasmid (Human) - CHJ6082 from Cohesion Biosciences
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COL22A1 miRNA 3'UTR clone - MiUTR1H-02314 from Creative biogene
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