LONP1

Gene Symbol	LONP1
Entrez Gene	9361
Alt Symbol	CODASS, LON, LONP, LonHS, PIM1, PRSS15, hLON
Species	Human
Gene Type	protein-coding
Description	lon peptidase 1, mitochondrial
Other Description	LONP|hLON ATP-dependent protease|lon protease homolog, mitochondrial|lon protease-like protein|mitochondrial ATP-dependent protease Lon|mitochondrial lon protease-like protein|serine protease 15
Swissprots	Q8N8K8 P36776 B3KPH8 E5KMH8 P36777 Q9UQ95 D6W635 F5GZ27
Accessions	AAD24414 ADP90374 ADP90375 ADP90376 ADP90377 ADP90378 ADP90379 ADP90380 ADP90381 ADP90382 ADP90383 ADP90384 ADP90385 ADP90386 ADP90387 ADP90388 ADP90389 ADP90390 ADP90391 ADP90392 ADP90393 ADP90394 ADP90395 ADP90396 ADP90397 ADP90398 ADP90399 ADP90400 ADP90401 ADP90402 ADP90403 ADP90404 ADP90405 ADP90406 ADP90407 ADP90408 ADP90409 ADP90410 ADP90411 ADP90412 ADP90413 EAW69151 EAW69152 EAW69153 EAW69154 P36776 AK056366 BAG51690 AK096433 BAG53290 AK096626 BAC04829 AK127867 BAG54587 AK298531 BAG60732 AK309720 AL096720 BC000235 AAH00235 BC109218 AAI09219 BC109219 BC139726 AAI39727 BI906625 DQ892955 ABM83881 DQ896202 ABM87201 U02389 AAA61616 XM_011528441 XP_011526743 NM_001276479 NP_001263408 NM_001276480 NP_001263409 NM_004793 NP_004784 NR_076392
Function	ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site- specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. {ECO:0000255|HAMAP- Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:8248235}.
Subcellular Location	Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03120, ECO:0000269|PubMed:7961901}.
Tissue Specificity	Duodenum, heart, lung and liver, but not thymus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LONP1 full length protein - ab160451 from Abcam Category Protein Source Wheat germ Species Human

Human LONP1 protein fragment - ab152974 from Abcam Category Protein Source Wheat germ Species Human

LONP1 / LON Antibody Blocking Peptide - LS-E6705 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIM1 / Pim-1 Antibody Blocking Peptide - LS-E2951 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIM1 / Pim-1 Antibody Blocking Peptide - LS-E20462 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIM1 / Pim-1 Antibody Blocking Peptide - LS-E20463 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIM1 / Pim-1 Antibody Blocking Peptide - LS-E9379 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIM1 / Pim-1 Antibody Blocking Peptide - LS-E9378 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIM1 Partial Recombinant Protein - H00005292-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

LONP1 Recombinant Protein - H00009361-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human LONP1 Protein - H00009361-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PIM1 Recombinant Protein - H00005292-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PIM1 Protein - NBP2-23333 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Species Human

PIM1 Recombinant Protein - P4225 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

PIM1 Recombinant Protein - P4751 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant PIM1 Protein - NBP1-99497 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

PIM1 Peptide - P2915 from Novus Biologicals Category Peptide Species Human

LONP1-AntibodyCenter-Blocking-peptide - BP19551c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIM1 (Active) recombinant protein - GTX65203 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Human PIM1 protein - orb191043 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli Species Human

PIM1 (OVA) peptide - orb197992 from Biorbyt Category Peptide Prices $434.00 Sizes 100 μg Species Human, Mouse, Rat, Rabbit, Guinea Pig, Monkey, Dog, Horse, Sheep

PIM1 Blocking Peptide - 33R-6196 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PIM1 Blocking Peptide - 33R-10916 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

PIM1 Blocking Peptide - 33R-10550 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

PIM1 Blocking Peptide - 33R-6195 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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